Article
Comparison of in vivo plasma and peripheral blood mononuclear cell HIV-1 quasi-species to short-term tissue culture isolates: an analysis of tat and C2-V3 env regions.
AIDS (London, England) - 1 Jul 1994
Sabino E, Pan L Z, Cheng-Mayer C, Mayer A
Abstract excerpt
OBJECTIVE: To determine whether the HIV-1 genomes that grow out in vitro from peripheral blood mononuclear cells (PBMC) better represent the in vivo quasi-species present in plasma or PBMC. RESULTS: For one patient (9606), PBMC culture represented more accurately the plasma rather than the in vivo PBMC quasi-species distribution, because a large number of tat-defective proviruses present in PBMC in vivo were not...
Topics
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- Cytopathogenic Effect, Viral
- DNA, Viral
- Genes, env
- Genes, tat
- Genetic Variation
- Genotype
- Glycosylation
- HIV Envelope Protein gp120