Article
Effect of target cell availability on HIV-1 production in vitro.
AIDS (London, England) - 15 Feb 2002
Schwartz Elissa J, Neumann Avidan U, Teixeira Avelino V, Bruggeman Leslie A, Rappaport Jay, Perelson Alan S, Klotman Paul E
Abstract excerpt
OBJECTIVE: The recovery of CD4 target cells following antiretroviral therapy may facilitate virus production and escape from antiretroviral suppression. To address this hypothesis, we directly examined whether the CD4 target cell number increases viral production in the presence of suboptimal therapy. DESIGN: The effect of the CD4 T cell number on HIV-1 replication with a suboptimal dose of zidovudine was studied...
Topics
- Anti-HIV Agents
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Genotype
- HIV Infections
- HIV-1
- Humans
- In Vitro Techniques
- Virus Replication
- Zidovudine