Article
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994
Gearing M, Rebeck G W, Hyman B T, Tigges J, Mirra S S
Abstract excerpt
Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in hu...
Topics
- Aging
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Apolipoproteins E
- Base Sequence
- Brain
- DNA Primers
- Female
- Genotype
- Humans
- Macaca mulatta
- Male
- Microscopy, Electron
- Molecular Sequence Data
- Neurofibrillary Tangles
- Pan troglodytes