Article
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994
Gearing M, Rebeck G W, Hyman B T, Tigges J, Mirra S S
Abstract excerpt
Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in human aging and Alzheimer disease. Neurofibrillary tangles, another hallmark of Alzheimer disease, were absent....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.