Article
Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype.
FEBS letters - 29 Jan 1996
Morelli L, Wei L, Amorim A, McDermid J, Abee C R, Frangione B, Walker L C, Levy E
Abstract excerpt
Some neuropathological changes characteristic of aging and Alzheimer's disease (AD) in humans are present also in senescent non-human primates. The human apoE4 allele is associated with an increased risk of developing late-onset familial and sporadic AD. We found that rhesus monkeys and three subspecies of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158 as in human apoE4....
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