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Article

The two faces of myeloproliferative neoplasms: Molecular events underlying lymphoid transformation.

Leukemia research - 1 Oct 2011

Holroyd Ailsa, Cross Nicholas C P, Macdonald Donald H

Abstract excerpt

Multipotent haematopoietic stem cells pass through stages of differentiation with the progressive loss of developmental options leading to the production of terminally differentiated mature blood cells. This process is regulated by soluble cytokines binding to a ligand specific cell surface receptor on a precursor cell. Key to signal transduction are tyrosine kinase proteins which can be divided into two sub...

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Source

Identifiers

PMID: 21722956
DOI: 10.1016/j.leukres.2011.05.037

Genes

JAK2
FGFR1
JAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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