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Article

Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.

1 Oct 1994

Abstract excerpt

The ErbB3 protein is a member of the ErbB subfamily of receptor protein tyrosine kinases. In the present study, the mechanism by which the ErbB3 protein is phosphorylated and the signal-transducing functions of this phosphorylated protein were investigated. When phosphorylated by the epidermal growth factor receptor in vitro, the ErbB3 protein strongly associated with the regulatory p85 subunit and the catalytic...

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PMID: 7929151
DOI: 10.1016/s0021-9258(17)31455-2

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