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Article

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit.

Oncogene - 16 Feb 2012

Neal C L, Xu J, Li P, Mori S, Yang J, Neal N N, Zhou X, Wyszomierski S L, Yu D

Abstract excerpt

The ubiquitously expressed 14-3-3 proteins regulate many pathways involved in transformation. Previously, we found that 14-3-3ζ overexpression increased Akt phosphorylation in human mammary epithelial cells. Here, we investigated the clinical relevance and molecular mechanism of 14-3-3ζ-overexpression-mediated Akt phosphorylation, and its potential impact on breast cancer progression. We found that 14-3-3ζ...

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Share to 14-3-3 Proteins
Share to Amino Acid Substitution
Share to Class Ia Phosphatidylinositol 3-Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 21743495
DOI: 10.1038/onc.2011.284
PMCID: PMC3193867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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