Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis.

Article

Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis.

The Journal of biological chemistry - 30 Sept 1994

Muller E G

Abstract excerpt

Deletion of both thioredoxin genes TRX1 and TRX2 of Saccharomyces cerevisiae reduces the rate of DNA replication. This observation, originally determined by flow cytometry, was confirmed by radiochemical labeling of synchronized cultures. Since thioredoxin is a hydrogen donor to ribonucleotide re...

Topics

DNA Replication
DNA, Fungal
Deoxyribonucleotides
Mutation
Ribonucleotide Reductases
Saccharomyces cerevisiae
Thioredoxins

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