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Article

A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae.

Molecular microbiology - 1 Jun 2000

Draculic T, Dawes I W, Grant C M

Abstract excerpt

Glutaredoxins and thioredoxins are small heat-stable oxidoreductases that have been conserved throughout evolution. The yeast Saccharomyces cerevisiae contains two gene pairs encoding cytoplasmic glutaredoxins (GRX1, GRX2) and thioredoxins (TRX1, TRX2). We report here that the quadruple trx1 trx2 grx1 grx2 mutant is inviable and that either a single glutaredoxin or a single thioredoxin (i.e. grx1 grx2 trx1, grx1...

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PMID: 10844700
DOI: 10.1046/j.1365-2958.2000.01948.x

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