Article
Amino-terminal conserved region in proteinase inhibitor domain of calpastatin potentiates its calpain inhibitory activity by interacting with calmodulin-like domain of the proteinase.
The Journal of biological chemistry - 30 Sept 1994
Ma H, Yang H Q, Takano E, Hatanaka M, Maki M
Abstract excerpt
Calpastatin is a widely distributed endogenous inhibitor protein specifically acting on calpain (Ca(2+)-dependent proteinase) and is known to interact with the calmodulin-like domain (CaMLD) of the proteinase in a Ca(2+)-dependent fashion. The calpastatin molecule consists of four inhibitory doma...
Topics
- Amino Acid Sequence
- Animals
- Calcium-Binding Proteins
- Calmodulin
- Calpain
- Conserved Sequence
- Cysteine Proteinase Inhibitors
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- Swine