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Article

Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.

1 Apr 1992

Abstract excerpt

Calpastatin, a specific inhibitor of calpain, consists of a unique N-terminal domain (domain L) and four repetitive calpain-inhibition domains (domains 1-4). Calpastatin cDNA of human was reported to have two deletions in domains L and 1, as compared with that of pig and rabbit. We isolated human calpastatin genomic DNA clones, and the sequence analysis revealed seven exons for domain L and five exons for domain...

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PMID: 1569094
DOI: 10.1016/s0021-9258(18)42463-5

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