Article
The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin.
International journal of cancer - 15 Oct 1994
Xu F J, Boyer C M, Bae D S, Wu S, Greenwald M, O'Briant K, Yu Y H, Mills G B, Bast R C
Abstract excerpt
Our previous studies have demonstrated that 7 of 10 IgG antibodies against distinct epitopes on the extracellular domain of the c-erbB-2 gene product (p185) inhibit the anchorage-independent growth of SKBr3 human breast-cancer cells that overexpress this transmembrane tyrosine kinase growth-facto...
Topics
- 3T3 Cells
- Animals
- Antibodies
- Breast Neoplasms
- Cell Adhesion
- Cell Division
- Humans
- Immunotoxins
- Intracellular Fluid
- Mice
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptor, ErbB-2