Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice.

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Article

Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice.

Cancer research - 15 May 1990

Engert A, Martin G, Pfreundschuh M, Amlot P, Hsu S M, Diehl V, Thorpe P

Abstract excerpt

Three monoclonal antibodies which strongly bind to Hodgkin and Reed-Sternberg cells and two corresponding Fab' fragments were linked to deglycosylated ricin A chain (dg A) to evaluate their potential as immunotoxins for the treatment of Hodgkin's disease. Two of the antibodies, Ber-H2 and HRS-3, were shown to bind to the same epitope on the CD30 antigen, whereas the third antibody, IRac, bound to a different...

Topics

Animals
Antibodies, Monoclonal
Antibody Specificity
Antigens, CD
Antigens, Differentiation
Antigens, Neoplasm
Epitopes
Hodgkin Disease
Humans
Immunoglobulin Fab Fragments
Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunotoxins

Ki-1 Antigen

Mice

Mutation

Neoplasm Transplantation

Ricin

Source

Open in PubMed

Identifiers

PMID: 1692251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1692251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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