Article
Positive feedback in the activation of G1 cyclins in yeast.
Nature - 27 Jun 1991
Dirick L, Nasmyth K
Abstract excerpt
Yeast cells become committed to the mitotic cell cycle at a stage during G1 called Start. To enter Start, cells must grow to a critical size. They also require the CDC28 protein kinase and at least one of three G1-specific cyclins encoded by CLN1, 2, and 3. It is thought that Start is triggered by the accumulation of G1 cyclins that bind to the CDC28 kinase and activate it. So what determines the accumulation of...
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