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Article

HLA associations with inclusion body myositis

1 Oct 1994

Abstract excerpt

Inclusion body myositis (IBM) is defined clinically by a characteristic pattern of progressive proximal and distal limb muscle weakness and resistance to steroid therapy, and histologically by the presence of distinctive rimmed vacuoles and filamentous inclusions as well as a mononuclear infiltrate in which CD8+ T cells are predominant. Muscle damage is believed to be mediated by autoimmune mechanisms, but very...

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Identifiers

PMID: 7923882
DOI: 10.1111/j.1365-2249.1994.tb06604.x

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