Comparison of genomic abnormality in malignant mesothelioma by the site of origin

doi:10.1136/jclinpath-2014-202465

Article

Comparison of genomic abnormality in malignant mesothelioma by the site of origin

12 Sept 2014

Abstract excerpt

AIMS: Malignant mesothelioma (MM) results from the accumulation of a number of acquired genetic events at the onset. In MM, the most frequent changes are losses in 9p21, 1p36, 22q12 and 14q32, and gains in 5p, 7p and 8q24 by comparative genomic hybridisation analysis. We have examined various genomic losses and gains in MM and benign mesothelial proliferation by fluorescence in situ hybridisation (FISH) analysis....

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