A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion.

doi:10.1038/ng0694-143

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Article

A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion.

Nature genetics - 1 Jun 1994

Holmes S E, Dombroski B A, Krebs C M, Boehm C D, Kazazian H H

Abstract excerpt

We have found a 2 kilobase insertion containing a rearranged L1 element in the dystrophin gene of a muscular dystrophy patient. We cloned the precursor of this insertion, the second known active human L1 element. The locus, LRE2, has one allele derived from the patient which matches the insertion...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 1
Cloning, Molecular
DNA
DNA Primers
Dystrophin
Female
Humans
Male
Molecular Sequence Data
Muscular Dystrophies
Pedigree
Polymorphism, Genetic
Retroelements

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