Lysine-146 of rabbit muscle aldolase is essential for cleavage and condensation of the C3-C4 bond of fructose 1,6-bis(phosphate).

doi:10.1021/bi00206a036

Back to search

Article

Lysine-146 of rabbit muscle aldolase is essential for cleavage and condensation of the C3-C4 bond of fructose 1,6-bis(phosphate).

Biochemistry - 11 Oct 1994

Morris A J, Tolan D R

Abstract excerpt

Lysine-146 of rabbit muscle aldolase (D-fructose-1,6-biphosphate aldolase, EC 4.1.2.13) is absolutely conserved in class I (Schiff base) aldolases and has been implicated previously in catalysis by protein modification. Site-directed mutagenesis was used to change lysine-146 to alanine, glutamine...

Topics

Animals
Base Sequence
Catalysis
Codon
Fructose-Bisphosphate Aldolase
Fructosediphosphates
Hydrogen-Ion Concentration
Lysine
Molecular Sequence Data
Muscles
Mutagenesis, Site-Directed
Mutation
Oligodeoxyribonucleotides
Rabbits
Schiff Bases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.