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Article

The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation.

Cell - 16 Jul 1993

Ebens A J, Garren H, Cheyette B N, Zipursky S L

Abstract excerpt

The Drosophila anachronism (ana) locus controls the proliferation of neuroblasts, neuronal stem cells that give rise to the central nervous system. In ana mutants, quiescent postembryonic central brain and optic lobe neuroblasts enter S phase precociously. ana encodes a novel secreted protein of 474 amino acids that is expressed not in the affected neuroblasts, but rather in a subclass of neighboring glial cells....

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PMID: 7916657
DOI: 10.1016/0092-8674(93)90291-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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