Article
Cell type-specific heterogeneity of the HIV-1 V3 loop in infected individuals: selection of virus in macrophages and plasma.
Virology - 1 Oct 1994
Yamashita A, Yamamoto N, Matsuda J, Koyanagi Y
Abstract excerpt
The primary targets for infection of HIV-1 are CD4+ T cells and monocyte/macrophage cells. We investigated the genotype heterogeneity of HIV-1 in distinct blood compartments, CD4+ T cells, monocytes, and plasma. Nucleotide sequences of proviral DNA from CD4+ T cells, monocyte cells, and cell-free...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- DNA, Viral
- Genes, env
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Macrophages
- Male
- Molecular Sequence Data
- Monocytes
- Peptide Fragments
- Protein Structure, Secondary