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Article

Cell type-specific heterogeneity of the HIV-1 V3 loop in infected individuals: selection of virus in macrophages and plasma.

Virology - 1 Oct 1994

Yamashita A, Yamamoto N, Matsuda J, Koyanagi Y

Abstract excerpt

The primary targets for infection of HIV-1 are CD4+ T cells and monocyte/macrophage cells. We investigated the genotype heterogeneity of HIV-1 in distinct blood compartments, CD4+ T cells, monocytes, and plasma. Nucleotide sequences of proviral DNA from CD4+ T cells, monocyte cells, and cell-free virion RNA from plasma were determined in three HIV-1 infected individuals. We found that the heterogeneity in...

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PMID: 7916512
DOI: 10.1006/viro.1994.1521

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