A manganese superoxide dismutase (SOD2) gene polymorphism in insulin-dependent diabetes mellitus.

doi:10.1155/1993/678310

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Article

A manganese superoxide dismutase (SOD2) gene polymorphism in insulin-dependent diabetes mellitus.

Disease markers - 1 Dec 1993

Pociot F, Lorenzen T, Nerup J

Abstract excerpt

Interleukin 1 (IL-1) is selectively cytotoxic to the insulin producing beta cell of pancreatic islets. This effect may be due to IL-1 induced generation of reactive oxygen species and nitric oxide. Since beta cells contain low amounts of the superoxide radical scavenger enzyme manganese superoxid...

Topics

Alleles
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus, Type 1
Gene Frequency
Genetic Linkage
Genotype
Humans
Manganese
Polymorphism, Restriction Fragment Length
Superoxide Dismutase

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