Article
Enhancement of Adriamycin cytotoxicity in a multidrug resistant Chinese hamster ovary (CHO) subline, CHO-Adrr, by toremifene and its modulation by alpha 1 acid glycoprotein.
European journal of cancer (Oxford, England : 1990) - 1 Apr 1990
Chatterjee M, Harris A L
Abstract excerpt
The effects of a new antioestrogen, toremifene, on multidrug resistance have been studied in a Chinese hamster ovary parental line, CHO-K1, and in a multidrug resistance subline, CHO-Adrr. Toremifene at subinhibitory concentrations increased the cytotoxic effectiveness of Adriamycin in both cell...
Topics
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- Doxorubicin
- Drug Resistance
- Drug Synergism
- Estrogen Antagonists
- Female
- Orosomucoid
- Ovary
- Phenotype
- Protein Binding
- Tamoxifen
- Toremifene