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Article

Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.

Cancer chemotherapy and pharmacology - 1 Sept 2011

Takakuwa Osamu, Oguri Tetsuya, Ozasa Hiroaki, Uemura Takehiro, Kasai Daishi, Miyazaki Mikinori, Maeno Ken, Sato Shigeki

Abstract excerpt

PURPOSE: Amrubicin, a totally synthetic 9-aminoanthracycline anticancer drug, has shown promising activity for lung cancer, but little is known about the mechanism of resistance for this agent. This study was aimed to clarify the role of P-glycoprotein (P-gp) in amrubicinol, an active metabolite of amrubicin, resistance in lung cancer cells. METHODS: Amrubicinol-resistant cell line PC-6/AMR-OH was developed by...

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PMID: 21128075
DOI: 10.1007/s00280-010-1533-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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