Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins. II. Perturbations of post-translational nuclear protein modification.

doi:10.1016/0306-9877(78)90010-5

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Article

Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins. II. Perturbations of post-translational nuclear protein modification.

Medical hypotheses - 1 Jan 2000

Hancock R L

Abstract excerpt

An hypothesis of carcinogenesis is derived which suggests that carcinogens initially induce derepressions of structional genes of post-translational modifying enzymes. Although the resulting cascade of changes in genic activity would be measureable because of the large number of differentiated cells present in a tissue, only stem cells are vulnerable to the neoplastic array of genic expression by virtue of their...

Topics

Animals
DNA
Ethionine
Histones
Liver
Methionine
Neoplasms
Ovalbumin
Phenotype
Protein Biosynthesis
Rats
Suppression, Genetic

Transcription, Genetic

alpha-Fetoproteins

tRNA Methyltransferases

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