Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins. II. Perturbations of post-translational nuclear protein modification.

Abstract excerpt

An hypothesis of carcinogenesis is derived which suggests that carcinogens initially induce derepressions of structional genes of post-translational modifying enzymes. Although the resulting cascade of changes in genic activity would be measureable because of the large number of differentiated cells present in a tissue, only stem cells are vulnerable to the neoplastic array of genic expression by virtue of their...

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