Article
Nakahara Memorial Lecture. Pathways of carcinogenesis--genetic and epigenetic.
Princess Takamatsu symposia - 1 Jan 1991
Pitot H C, Dragan Y, Xu Y H, Peterson J, Hully J, Campbell H
Abstract excerpt
Considerable experimental evidence has developed to argue that carcinogenesis occurs in a series of stages whose characteristics allow division into the distinct stages of initiation, promotion, and progression. The stage of initiation results from subtle genetic alterations in individual target cells caused both by experimental perturbations as well as by ambient environmental factors. Initiation of a cell may...
Topics
- Animals
- Carcinogens
- Cocarcinogenesis
- Gene Expression Regulation
- Humans
- Mutation
- Neoplasms