Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.

doi:10.1016/0165-4608(94)90004-3

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Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.

Cancer genetics and cytogenetics - 1 Jun 1994

Dahir G A, Vnencak-Jones C L, Schwartz H S, Butler M G

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Several studies have shown that giant cell tumor of bone frequently exhibits telomeric associations, commonly at chromosome 11p, which is also the location of the H-ras oncogene. In addition, rare H-ras alleles are more common among cancer patients than among healthy controls and point mutations of this oncogene have also been reported in several malignancies. These data led us to investigate gene dosage,...

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Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.

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