Article
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
Cancer genetics and cytogenetics - 1 Jun 1994
Dahir G A, Vnencak-Jones C L, Schwartz H S, Butler M G
Abstract excerpt
Several studies have shown that giant cell tumor of bone frequently exhibits telomeric associations, commonly at chromosome 11p, which is also the location of the H-ras oncogene. In addition, rare H-ras alleles are more common among cancer patients than among healthy controls and point mutations...
Topics
- Adult
- Alleles
- Base Sequence
- Blotting, Southern
- Bone Neoplasms
- Chromosome Deletion
- Female
- Genes, ras
- Giant Cell Tumor of Bone
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length