Article
DNA analysis of the SH3BP2 gene in patients with aggressive central giant cell granuloma.
The British journal of oral & maxillofacial surgery - 1 Sept 2007
de Lange Jan, van Maarle Merel C, van den Akker Hans P, Redeker Egbert J W
Abstract excerpt
A mutation of the SH3BP2 gene is known to cause cherubism. As there are clinical and histopathological similarities between central giant cell granuloma and cherubism, we made a constitutional DNA analysis of the SH3BP2 gene in four patients with aggressive giant cell granuloma (having one or more of the following features pain, paraesthesia, rapid growth, or root resorption). We found no mutations in the SH3BP2...
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