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Article

Crystal structure of the Vibrio cholerae colonization factor TcpF and identification of a functional immunogenic site.

Journal of molecular biology - 3 Jun 2011

Megli Christina J, Yuen Alex S W, Kolappan Subramaniapillai, Richardson Malcolm R, Dharmasena Madushini N, Krebs Shelly J, Taylor Ronald K, Craig Lisa

Abstract excerpt

Vibrio cholerae relies on two main virulence factors--toxin-coregulated pilus (TCP) and cholera toxin--to cause the gastrointestinal disease cholera. TCP is a type IV pilus that mediates bacterial autoagglutination and colonization of the intestine. TCP is encoded by the tcp operon, which also encodes TcpF, a protein of unknown function that is secreted by V. cholerae in a TCP-dependent manner. Although TcpF is...

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Identifiers

PMID: 21440558
DOI: 10.1016/j.jmb.2011.03.027
PMCID: PMC3098003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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