A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.

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Article

A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.

The Journal of biological chemistry - 27 May 1994

Jensen P H, Schüler E, Woodrow G, Richardson M, Goss N, Højrup P, Petersen T E, Rasmussen L K

Abstract excerpt

Plasminogen activator inhibitor type 2 (PAI-2) prevents fibrinolysis by blocking plasminogen activators. It is expressed principally by trophoblast cells and macrophages. PAI-2 in trophoblast membranes has been found cross-linked to large complexes apparently catalyzed by trophoblast transglutaminase (Jensen, P. H., Lorand, L., Ebbesen, P., and Gliemann, J. (1993) Eur. J. Biochem. 214, 141-146). Recombinant human...

Topics

Amino Acid Sequence
Animals
Chromatography, High Pressure Liquid
Cross-Linking Reagents
Glutamine
Guinea Pigs
Humans
Liver
Mass Spectrometry
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Mapping

Plasminogen Activator Inhibitor 2

Protein Conformation

Recombinant Proteins

Transglutaminases

Source

Open in PubMed

Identifiers

PMID: 7910824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7910824-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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