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Article

Loss of heterozygosity of the thyroid hormone receptor B in posterior uveal melanoma

1 Nov 1993

Abstract excerpt

Cytogenetic investigations of posterior uveal melanomas have identified non-random changes of chromosomes 3, 6, and 8. Monosomy of chromosome 3 with additional copies of 8q occur principally in the subgroup of uveal melanomas arising from the ciliary body. To determine whether ciliary body and choroidal melanomas maintain submicroscopic differences in their genetic aetiology, studies of the loss of heterozygosity...

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PMID: 7909244
DOI: 10.1097/00008390-199311000-00009

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