Article
Correlation between gold-induced enterocolitis and the presence of the HLA-DRB1*0404 allele.
Arthritis and rheumatism - 1 Jun 1995
Evron E, Brautbar C, Becker S, Fenakel G, Abend Y, Sthoeger Z, Cohen P, Geltner D
Abstract excerpt
OBJECTIVE: In recent years we have treated 4 rheumatoid arthritis (RA) patients who developed gold-induced enterocolitis, a well-recognized, although rare, complication of chrysotherapy. The aim of the present study was to seek any genetic predisposition for this complication. METHODS: HLA DNA typing was done on fresh white blood cells from the 4 patients. RESULTS: Three of the 4 patients (75%) exhibited the...
Topics
- Adult
- Alleles
- Arthritis, Rheumatoid
- Causality
- DNA
- Enterocolitis
- Female
- Gene Frequency
- Gold
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Testing