Article
Proteus mirabilis fimbriae: construction of an isogenic pmfA mutant and analysis of virulence in a CBA mouse model of ascending urinary tract infection.
Infection and immunity - 1 Feb 1994
Massad G, Lockatell C V, Johnson D E, Mobley H L
Abstract excerpt
Proteus mirabilis, a cause of urinary tract infection and acute pyelonephritis, produces a number of different fimbriae. An isogenic fimbrial mutant of P. mirabilis HI4320 was constructed by marker exchange with delta pmfA::aphA to determine the role of the P. mirabilis fimbriae (PMF) in hemagglutination and in virulence in the CBA mouse model of ascending urinary tract infection. The pmfA mutant, which did not...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Bacterial
- Disease Models, Animal
- Female
- Fimbriae, Bacterial
- Genes, Bacterial
- Mice
- Mice, Inbred CBA
- Molecular Sequence Data