Article
Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection.
Infection and immunity - 1 Dec 1996
Mobley H L, Belas R, Lockatell V, Chippendale G, Trifillis A L, Johnson D E, Warren J W
Abstract excerpt
To examine the role of flagella in pathogenesis of urinary tract infection caused by Proteus mirabilis, we constructed a nonmotile, nonswarming flagellum mutant of strain WPM111 (an hpmA hemolysin mutant of strain BA6163, chosen because of its lack of in vitro cytotoxicity in renal epithelial cel...
Topics
- Animals
- Cells, Cultured
- Epithelium
- Flagella
- Humans
- Kidney
- Mice
- Mice, Inbred CBA
- Mutation
- Proteus Infections
- Proteus mirabilis
- Urinary Tract Infections
- Virulence