Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection.

doi:10.1128/iai.58.4.1120-1123.1990

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Article

Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection.

Infection and immunity - 1 Apr 1990

Jones B D, Lockatell C V, Johnson D E, Warren J W, Mobley H L

Abstract excerpt

Proteus mirabilis, a urease-producing uropathogen, causes serious urinary tract infections in humans. To specifically evaluate the contribution of urease to virulence, a mutation was introduced into P. mirabilis HI4320 by homologous recombination. Virulence was assessed in the CBA mouse model of...

Topics

Animals
Female
Mice
Mice, Inbred CBA
Mutation
Proteus mirabilis
Urease
Urinary Tract Infections
Virulence

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