Article
Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor.
The Journal of biological chemistry - 21 Jan 1994
Baude E J, Dignam S S, Olsen S R, Reimann E M, Uhler M D
Abstract excerpt
Although the protein kinase inhibitors (PKIs) are known to be potent and specific inhibitors of the catalytic (C) subunit of cAMP-dependent protein kinase, little is known about their physiological roles. Glutamate 203 of the C alpha isoform (C alpha E203) has been implicated in the binding of th...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Binding Sites
- Carrier Proteins
- Cloning, Molecular
- Cyclic AMP-Dependent Protein Kinases
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Genetic Variation
- Glutamates
- Glutamic Acid
- Intracellular Signaling Peptides and Proteins
- Kinetics
- Macromolecular Substances
- Mice