LACK OF EVIDENCE OF PERMANENT ENGRAFTMENT AFTER IN UTERO FETAL STEM CELL TRANSPLANTATION IN CONGENITAL HEMOGLOBINOPATHIES1

Abstract excerpt

The use of fetal hematopoietic stem cells for in utero transplantation to create permanent hematochimerism represents a new concept in fetal therapy. In one fetus with alpha-thalassemia, one with sickle cell anemia, and one with beta-thalassemia, we have transplanted fetal liver cells obtained from legal abortions in gestational weeks 6-11. The fetus with alpha-thalassemia was transplanted twice during pregnancy,...

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