Article
A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease.
Journal of biochemistry - 1 Aug 1993
Tsuneoka Y, Matsuo Y, Iwahashi K, Takeuchi H, Ichikawa Y
Abstract excerpt
Genetic polymorphism of the CYP2D6 gene [phenotypically individuals are either poor metabolizers (PM) or extensive metabolizers (EM)] has been reported to be associated with susceptibility to Parkinson's disease. We analyzed CYP2D6 genes from Japanese patients and controls, and found that EM/PM p...
Topics
- Arginine
- Base Sequence
- Cysteine
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Deoxyribonucleases, Type II Site-Specific
- Genotype
- Homozygote
- Humans
- Japan
- Mixed Function Oxygenases
- Molecular Sequence Data
- Mutation
- Parkinson Disease
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length