Article
Flow cytometric assessment of multidrug resistance (MDR) phenotype in acute myeloid leukaemia.
Leukemia & lymphoma - 1 Oct 1993
Hart S M, Ganeshaguru K, Lyttelton M P, Prentice H G, Hoffbrand A V, Mehta A B
Abstract excerpt
Forty one patients with acute myeloid leukemia (AML), including 27 at presentation and 14 relapsed or resistant cases, were assessed for laboratory evidence of the MDR phenotype. Leukaemic cells from all 41 cases were studied by immunocytochemistry using the JSB-1 monoclonal antibody and simultan...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Carrier Proteins
- Drug Resistance
- Female
- Flow Cytometry
- Humans
- Immunohistochemistry
- Leukemia, Myeloid, Acute
- Male
- Membrane Glycoproteins
- Middle Aged
- Phenotype
- Polymerase Chain Reaction
- RNA, Messenger