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Article

A large circular minichromosome of Schizosaccharomyces pombe requires a high dose of type II DNA topoisomerase for its stabilization.

Molecular & general genetics : MGG - 20 Mar 1995

Murakami S, Yanagida M, Niwa O

Abstract excerpt

We have constructed circular minichromosomes, ranging in size from 36 to 110 kb, containing the centromeric repeats of Schizosaccharomyces pombe cen3. Comparison of their mitotic stability showed that the circular minichromosomes became more unstable with increasing in size, however, a linear cen3 minichromosome, which is almost the same size as the largest circular one tested, does not show such instability....

Topics

Chromosomes, Fungal
DNA Topoisomerases, Type II
G2 Phase
Mitosis
Phenotype
Plasmids
Repetitive Sequences, Nucleic Acid
Ring Chromosomes
Schizosaccharomyces
Transformation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7898434
DOI: 10.1007/BF00290712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7898434-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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