Article
A role for ultraviolet A in solar mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995
Drobetsky E A, Turcotte J, Châteauneuf A
Abstract excerpt
It is well established that exposure to solar UVB (290-320 nm) gives rise to mutations in oncogenes and tumor suppressor genes that initiate the molecular cascade toward skin cancer. Although UVA (320-400 nm) has also been implicated in multistage photocarcinogenesis, its potential contribution t...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Base Composition
- Base Sequence
- CHO Cells
- Cricetinae
- DNA
- Frameshift Mutation
- Genes, Tumor Suppressor
- Humans
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Neoplasms, Radiation-Induced
- Oncogenes
- Point Mutation
- Sequence Deletion
- Skin Neoplasms