Article
Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene.
Infection and immunity - 1 Apr 1995
Fletcher H M, Schenkein H A, Morgan R M, Bailey K A, Berry C R, Macrina F L
Abstract excerpt
In a previous study we cloned and determined the nucleotide sequence of the prtH gene from Porphyromonas gingivalis W83. This gene specifies a 97-kDa protease which is normally found in the membrane vesicles produced by P. gingivalis and which cleaves the C3 complement protein under defined conditions. We developed a novel ermF-ermAM antibiotic resistance gene cassette, which was used with the cloned prtH gene to...
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