Article
Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations.
The American journal of pathology - 1 Feb 2003
Tierens Anne, Delabie Jan, Malecka Agnieszka, Wang Junbai, Gruszka-Westwood Alicja, Catovsky Daniel, Matutes Estella
Abstract excerpt
Splenic marginal zone lymphoma (also splenic lymphoma with villous lymphocytes) is a B-cell non-Hodgkin's lymphoma with a characteristic morphology and phenotype. We studied the pattern of somatic hypermutation of the rearranged immunoglobulin heavy chain genes on 23 cases and have correlated these data with survival as well as immunophenotypic and genetic characteristics of the cases. Two-thirds of the cases...
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