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Article

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)

Blood - 15 Mar 1995

Rosendaal F R, Koster T, Vandenbroucke J P, Reitsma P H

Abstract excerpt

Resistance to activated protein C (APC) is a common inherited risk factor for venous thrombosis, which is associated with a mutation in coagulation factor V (factor V Leiden). We investigated the risk of venous thrombosis in individuals homozygous for this abnormality. We determined the factor V Leiden genotype in 471 consecutive patients aged less than 70 years with a first objectively confirmed deep-vein...

Topics

Adult
Age Factors
Factor V
Female
Homozygote
Humans
Male
Middle Aged
Mutation
Protein C
Risk Factors
Thrombosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7888671

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7888671-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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