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Article

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)

Blood - 15 Mar 1995

Rosendaal F R, Koster T, Vandenbroucke J P, Reitsma P H

Abstract excerpt

Resistance to activated protein C (APC) is a common inherited risk factor for venous thrombosis, which is associated with a mutation in coagulation factor V (factor V Leiden). We investigated the risk of venous thrombosis in individuals homozygous for this abnormality. We determined the factor V Leiden genotype in 471 consecutive patients aged less than 70 years with a first objectively confirmed deep-vein...

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Identifiers

PMID: 7888671

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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