Article
Thrombosis in a patient with combined homozygosity for the factor V Leiden mutation and a mutation in the 3'-untranslated region of the prothrombin gene.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Mar 1999
Wulf G M, Van Deerlin V M, Leonard D G, Bauer K A
Abstract excerpt
The factor V Leiden mutation and a guanine-to-adenine mutation at nucleotide 20210 in the 3'-untranslated region of the prothrombin gene are the most prevalent genetic defects in patients with deep venous thrombosis. Heterozygosity for the factor V Leiden and the prothrombin gene mutations is found in approximately 20 and 6% of unselected patients with deep venous thrombosis, respectively, whereas the prevalences...
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