Article
Sequences in the preC region of duck hepatitis B virus affect pregenomic RNA accumulation.
Virology - 10 Mar 1995
Chang C, Hirsch R C, Ganem D
Abstract excerpt
The pregenomic RNA of hepadnaviruses serves as both the mRNA for the core and polymerase proteins and the RNA template for reverse transcription. We have identified a region in the duck hepatitis B virus pregenomic RNA transcription unit that is critical for the accumulation of this transcript. This 85-nt region, termed alpha, is located within the preC region; deletion of alpha results in drastically reduced...
Topics
- Animals
- Base Sequence
- Cell Line
- DNA, Viral
- Genome, Viral
- Hepatitis Virus, Duck
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- RNA, Viral
- Sequence Deletion
- Transcription, Genetic