Article
Rejection of kidney allografts by MHC class I-deficient mice.
Transplantation - 15 Mar 1995
Mannon R B, Nataraj C, Kotzin B L, Griffiths R, Geier S, Ibrahim S, Sanfilippo F P, Platt J L, Kurlander R, Coffman T M
Abstract excerpt
To evaluate the requirement for CD8+ T cells in kidney transplant rejection, we studied class I-deficient (class I-) mice that had received vascularized renal allografts. Because of the absence of MHC class I expression, these mice are grossly deficient in CD4-CD8+ alpha beta TCR+ cells. Despite...
Topics
- Animals
- B-Lymphocytes
- CD4-CD8 Ratio
- CD8-Positive T-Lymphocytes
- Graft Rejection
- H-2 Antigens
- Histocompatibility Antigens Class I
- Kidney Transplantation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Phenotype
- Transplantation, Homologous