Article
Rejection of kidney allografts by MHC class I-deficient mice.
Transplantation - 15 Mar 1995
Mannon R B, Nataraj C, Kotzin B L, Griffiths R, Geier S, Ibrahim S, Sanfilippo F P, Platt J L, Kurlander R, Coffman T M
Abstract excerpt
To evaluate the requirement for CD8+ T cells in kidney transplant rejection, we studied class I-deficient (class I-) mice that had received vascularized renal allografts. Because of the absence of MHC class I expression, these mice are grossly deficient in CD4-CD8+ alpha beta TCR+ cells. Despite the deficiency of CD8+ T cells in naive class I- mice, kidney allografts transplanted into class I- recipients...
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