Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection.

Blood - 15 Sept 1998

Martin P J, Akatsuka Y, Hahne M, Sale G

Abstract excerpt

Donor CD8 cells play a pivotal role in preventing allogeneic marrow graft rejection, possibly by generating cytotoxic effectors needed to eliminate recipient T cells remaining after the pretransplant conditioning regimen or by producing cytokines needed to support the growth and differentiation of hematopoietic stem cells. In the present study, we assessed the role of donor T-cell cytotoxic effector function as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to CD8-Positive T-Lymphocytes
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Graft Rejection

Share to Mice, Inbred C57BL

Share to Mutation

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 9731078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection.PMID 9731078Read ↗

Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans.Semantic proximity Read ↗

Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.Semantic proximity Read ↗

CD8+ regulatory T cells in solid organ transplantationSemantic proximity Read ↗

Alloreactive T cells that do not require TCR and CD8 coengagement are present in naive mice and contribute to graft rejection.Semantic proximity Read ↗

Allograft recognition by recipient's natural killer cells: Molecular mechanisms and role in transplant rejection.Semantic proximity Read ↗

NK cells after transplantation: friend or foe.Semantic proximity Read ↗

NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCTSemantic proximity Read ↗

Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent MechanismSemantic proximity Read ↗

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes.Semantic proximity Read ↗

Suppression of allograft rejection by CD8+CD122+PD-1+ Tregs is dictated by their Fas ligand-initiated killing of effector T cells versus Fas-mediated own apoptosis.Semantic proximity Read ↗

Cytotoxic effector function of CD4-independent, CD8(+) T cells is mediated by TNF-α/TNFR.Semantic proximity Read ↗

CD4+ AND CD8+ T CELLS EACH CAN UTILIZE A PERFORIN-DEPENDENT PATHWAY TO MEDIATE LETHAL GRAFT-VERSUS-HOST DISEASE IN MAJOR HISTOCOMPATIBILITY COMPLEX-DISPARATE RECIPIENTS1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.