Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection.

Article

Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection.

Blood - 15 Sept 1998

Martin P J, Akatsuka Y, Hahne M, Sale G

Abstract excerpt

Donor CD8 cells play a pivotal role in preventing allogeneic marrow graft rejection, possibly by generating cytotoxic effectors needed to eliminate recipient T cells remaining after the pretransplant conditioning regimen or by producing cytokines needed to support the growth and differentiation o...

Topics

Animals
Bone Marrow Transplantation
CD8-Positive T-Lymphocytes
Cytotoxicity, Immunologic
Female
Graft Rejection
Graft vs Host Disease
Male
Mice
Mice, Inbred C57BL
Mutation
T-Lymphocytes, Cytotoxic

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