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Article

The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism.

Cellular immunology - 1 Nov 1992

Vitale M, Zamai L, Neri L M, Galanzi A, Facchini A, Rana R, Cataldi A, Papa S

Abstract excerpt

In order to study the fine mechanisms that underlie the impairment of non-MHC-restricted cytolytic activity which occurs during human aging, we examined by multiparametric flow cytometry the binding and lytic activities of human natural killer cells. The flow analysis revealed a striking increase of the CD16+8- subset, together with a significant decrease of CD8bright cells and total T cells (CD3+). Aging had no...

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Identifiers

PMID: 1423637
DOI: 10.1016/0008-8749(92)90307-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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