Article
The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism.
Cellular immunology - 1 Nov 1992
Vitale M, Zamai L, Neri L M, Galanzi A, Facchini A, Rana R, Cataldi A, Papa S
Abstract excerpt
In order to study the fine mechanisms that underlie the impairment of non-MHC-restricted cytolytic activity which occurs during human aging, we examined by multiparametric flow cytometry the binding and lytic activities of human natural killer cells. The flow analysis revealed a striking increase of the CD16+8- subset, together with a significant decrease of CD8bright cells and total T cells (CD3+). Aging had no...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aging
- Cells, Cultured
- Cytotoxicity, Immunologic
- Humans
- Killer Cells, Natural
- Lymphocyte Subsets
- Male
- Phenotype
- Receptors, IgG