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Article

Persistence of CD16+/CD56-/2B4+ natural killer cells: a highly dysfunctional NK subset expanded in ocular myasthenia gravis.

Journal of neuroimmunology - 1 Oct 2006

Nguyen Stéphanie, Morel Véronique, Le Garff-Tavernier Magali, Bolgert Francis, Leblond Véronique, Debré Patrice, Vieillard Vincent

Abstract excerpt

We report a case of myasthenia gravis associated with marked expansion of an unusual CD16(+)CD56(-)2B4(+) NK subset. These atypical cells were characterized by poor cytotoxicity against CD48(+) target cells and high proliferation due to 2B4/CD48 interaction. IL18, IFN-gamma and TGF-beta levels were profoundly different in this patient than in healthy donors. Immunosuppressive treatment induced disease remission...

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Identifiers

PMID: 16904757
DOI: 10.1016/j.jneuroim.2006.05.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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