Article
Mammary stem cell repertoire: new insights in aging epithelial populations.
Mechanisms of ageing and development - 1 Sept 2002
Smith Gilbert H, Boulanger Corinne A
Abstract excerpt
The proliferative lifespan of mammary stem cells was examined in serially transplanted clonal-dominant epithelial populations. Five successive transplant generations were done. The epithelial cell number in each outgrowth expands approximately 500-fold in nulliparous hosts and approximately 10000-fold in impregnated hosts. Despite this, all resulting mammary outgrowths showed lineal identity with the original....
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